Glimepiride is used in people with type 2 diabetes to minimize elevated blood sugar levels with a balanced diet and exercise in combination.
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Not recommended to take Secrin 2mg Tablet with alcohol. Alcohol intake may increase or decrease the blood sugar-lowering action of Secrin 2mg Tablet in an unpredictable way, resulting in a harmful event.
Secrin 2mg Tablet is a pregnancy Category C medicine, indicating that there are no well-controlled studies conducted on pregnant women. If you are taking GLIMEPIRIDE during pregnancy, stop taking it at least 2 weeks before your due date or as prescribed by your doctor.
Not recommended to be taken by breastfeeding mothers. Secrin 2mg Tablet may pass into breast milk and may pose the risk of low blood sugar in the infant. Consult your doctor for further advice.
Not recommended in patients with fluctuating glucose levels. Glimepiride can reduce the ability to concentrate or react if your blood sugar is lowered (hypoglycemia) or raised (hyperglycemia) or if you develop visual problems as a result of such conditions. Thus, it is not recommended as the patient can endanger himself or others (e.g. when driving a car or using machines).
Not recommended in patients with kidney dysfunction. A patient should consult a doctor before taking GLIMEPIRIDE as it may cause kidney damage.
Not recommended in patients with liver dysfunction. A patient should consult a doctor before taking Glimepiride as it may cause liver damage.
Secrin 2mg Tablet acts as an antidiabetic medication by increasing the release of insulin from the pancreas, thereby lowering blood glucose levels.
Hypoglycemia, headache, nausea, dizziness. Rare: Allergic skin reactions, cholestasis, elevation of liver enzyme levels.
Glimepiride is a sulfonylurea antidiabetic agent that reduces blood glucose concentration. Its primary mechanism of action involves stimulating the release of insulin from functional pancreatic beta cells. Glimepiride acts in concert with glucose by improving the sensitivity of beta cells to physiological glucose stimulation, resulting in insulin secretion. Additionally, extrapancreatic effects such as a reduction in basal hepatic glucose production, increased peripheral tissue sensitivity to insulin, and glucose uptake may also contribute to the action of Glimepiride. In non-fasting diabetic patients, the hypoglycemic activity of a single dose of Glimepiride persists for 24 hours.
Adult Dose:
Child Dose:
Renal Dose:
Administration:
Interactions that may potentiate the hypoglycemic activity of Glimepiride include ACE inhibitors, anabolic steroids, azapropazone, chloramphenicol, coumarin derivatives, fluconazole, MAO inhibitors, probenecid, quinolones, salicylates, sulfonamide antibiotics, and more. Drugs that may diminish the hypoglycemic activity include barbiturates, calcium channel blockers, corticosteroids, diazoxide, diuretics, glucagon, isoniazid, nicotinic acid, phenothiazines, rifampicin, sympathomimetic agents, thyroid hormones, and others.
Glimepiride is not suitable for the treatment of insulin-dependent (Type I) diabetes mellitus, diabetic ketoacidosis, or diabetic coma. It should not be used in patients allergic to Glimepiride, other sulfonylureas, other sulfonamides, severe hepatic dysfunction, severe impairment of renal function, or dialysis patients.
Glimepiride is contraindicated during pregnancy, and a transition to insulin is necessary. Breastfeeding women should not take Glimepiride as it may harm the baby. Transitioning or complete cessation of breastfeeding is necessary.
Increased risk of CV mortality, monitor blood glucose concentration. Caution in the elderly, hepatic and renal impairment, and SIADH in patients with CHF or hepatic cirrhosis. Pregnancy, lactation.
Store below 30°C temperature, protected from light and moisture. Keep out of the reach of children.
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